Role of Moringa oleifera in regulation of diabetes-induced oxidative stress

AbstractObjectiveTo evaluate the antioxidant activity of aqueous extract ofMoringa oleifera (M. oleifera) young leaves by in vivo as well as in vitro assays.MethodsIn vitro study included estimation of total phenolic, total flavonol, total flavonoid and total antioxidant power (FRAP assay). In addition, in vivo study was done with the identified most effective dose of 200 mg/kg of its lyophilized powder on normal and diabetic rats. Its effect on different oxidative free radical scavenging enzymes,viz, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), lipid peroxide (LPO) contents were measured.ResultsSignificant increase in activities of SOD, CAT, GST while, a decrease in LPO content was observed. Whereas, total phenolic, flavonoid and flavonol contents in the extract were found to be 120 mg/g of GAE, 40.5 mg/g of QE and 12.12 mg/g of QE, respectively. On the other hand, FRAP assay results ofM. oleifera leaves was (85.00±5.00)μM/g of extract powder.ConclusionsThe significant antioxidant activities ofM. oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage

Isolated Execution on Many-core Architectures

We explore how many-core platforms can be used to enhance the security of future systems and to support important security properties such as runtime isolation using a small Trusted Computing Base (TCB). We focus on the Intel Single-chip Cloud Computer (SCC) to show that such properties can be implemented in current systems. We design a system called \archname{} which offers strong security properties while maintaining high performance and flexibility enabled by a small centralized security kernel. We further implement and evaluate the feasibility of our design. Currently, our prototype security kernel is able to execute applications in isolation and accommodate dynamic resource requests from them. We show that, with minor modifications, many-core architectures can offer some unique security properties, not supported by existing single- and multi-core architectures, such as application context awareness. Context awareness, a new security property that we define and explore in this work, allows each application to discover, without any interaction with the security kernel, which other parts of the system are allowed to interact with it and access its resources. We also discuss how an application can use context awareness to defend itself from an unlikely, yet potentially compromised security kernel

Sex Change and the Popular Press : Historical Notes on Transsexuality in the United States, 1930-1955, Meyerowitz, Joanne

本稿はデューク大学出版の季刊誌『レズビアン&ゲイ・スタディーズ』(GLQ)のトランスジェンダー特集号(1998年)で発表された、歴史学者ジョアン・マイエロウィッツの論文の翻訳である。[Meyerowitz, Joanne, Sex Change and the Popular Press: Historical Notes on Transsexuality in the United States, 1930-1955, GLQ: A Journal of Lesbian and Gay Studies, 4:2 (1998), pp.159-187.] マイエロウィッツはこの論文のなかで、従来のトランスセクシュアリティに関する歴史認識の見直しを主張する。そして、20世紀初めにヨーロッパで興った性別変更の医療化の過程、さらに、1930-50年代のアメリカで公表された性別変更の報道などの分析を通じて、当時のトランスジェンダーの人びとが、「読むこと」を通じて、自己のアイデンティティを構築し、再形成していった過程を明らかにしている。なお、マイエロウィッツは現在インディアナ大学の歴史学教授で、The Journal of American Historyの編集者でもある。主な編著書: How Sex Changed: A History of Transsexuality in the United States (Harvard UP, 2002); History and September 11th: Critical Perspectives on the Past (Temple UP, 2003)ほか

Real-time worst-case temperature analysis with temperature-dependent parameters

With the evolution of today's semiconductor technology, chip temperature increases rapidly mainly due to the growth in power density. Therefore, for modern embedded real-time systems it is crucial to estimate maximal temperatures early in the design in order to avoid burnout and to guarantee that the system can meet its real-time constraints. This paper provides answers to a fundamental question: What is the worst-case peak temperature of a real-time embedded system under all feasible scenarios of task arrivals? Anovel thermal-aware analytic framework is proposed that combines a general event/resource model based on network and real-time calculus with system thermal equations. This analysis framework has the capability to handle a broad range of uncertainties in terms of task execution times, task invocation periods, jitter in task arrivals, and resource availability. The considered model takes both dynamic and leakage power as well as thermal dependent conductivity into consideration. Thorough simulation experiments validate the theoretical result

Carriage Prevalence of Carbapenem Resistant Enterobacteriaceae in Stool Samples: A Surveillance Study

BackgroundWith more people being exposed to antibiotics, intestinal microflora faces constant pressure of antibiotic selection, which has resulted in the emergence of multidrug resistant strains. This may pose a severe problem as intestinal Enterobacteriaceae members are commonly implicated in human infections.   AimsThis surveillance study was undertaken to investigate the carriage of carbapenem-resistant Enterobacteriaceae (CRE) in the gastrointestinal tract among patients attending the outpatient clinic in a tertiary care center of East Delhi, India. MethodWe performed a prospective surveillance study to screen 242 Enterobacteriaceae isolates for carbapenemase production from the stool samples of 123 outpatients attending a tertiary care hospital in East Delhi over a four-month period. ResultsTwenty-four (9.9 per cent) isolates demonstrated carbapenemase activity among 242 screened Enterobacteriaceae isolates. Four stool samples had two isolates of different species, both eliciting this feature and therefore indicating presence of multiple carbapenem-resistant Enterobacteriaceae (CRE) isolates in a single sample. ConclusionScreening for carriage of CRE in stools of patients undergoing elective or emergency gastrointestinal surgical procedures, with haematological malignancies taking chemotherapy, or those planned for bone marrow transplantation can guide clinicians about gut colonisation of multidrug-resistant Enterobacteriaceae as these groups of patients are at risk of possible endogenous infection.

Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

Foot-and-Mouth Disease Virus (FMDV) is a picornavirus that infects cloven-hoofed animals and leads to severe losses in livestock production. In the case of an FMD outbreak, emergency vaccination requires at least 7 days to trigger an effective immune response. There are currently no approved inhibitors for the treatment or prevention of FMDV infections.Using a luciferase-based assay we screened a library of compounds and identified seven novel inhibitors of 3Dpol, the RNA-dependent RNA polymerase of FMDV. The compounds inhibited specifically 3Dpol (IC(50)s from 2-17 µM) and not other viral or bacterial polymerases. Enzyme kinetic studies on the inhibition mechanism by compounds 5D9 and 7F8 showed that they are non-competitive inhibitors with respect to NTP and nucleic acid substrates. Molecular modeling and docking studies into the 3Dpol structure revealed an inhibitor binding pocket proximal to, but distinct from the 3Dpol catalytic site. Residues surrounding this pocket are conserved among all 60 FMDV subtypes. Site directed mutagenesis of two residues located at either side of the pocket caused distinct resistance to the compounds, demonstrating that they indeed bind at this site. Several compounds inhibited viral replication with 5D9 suppressing virus production in FMDV-infected cells with EC(50) = 12 µM and EC(90) = 20 µM).We identified several non-competitive inhibitors of FMDV 3Dpol that target a novel binding pocket, which can be used for future structure-based drug design studies. Such studies can lead to the discovery of even more potent antivirals that could provide alternative or supplementary options to contain future outbreaks of FMD

Habitat 3.0: A Co-Habitat for Humans, Avatars and Robots

We present Habitat 3.0: a simulation platform for studying collaborative human-robot tasks in home environments. Habitat 3.0 offers contributions across three dimensions: (1) Accurate humanoid simulation: addressing challenges in modeling complex deformable bodies and diversity in appearance and motion, all while ensuring high simulation speed. (2) Human-in-the-loop infrastructure: enabling real human interaction with simulated robots via mouse/keyboard or a VR interface, facilitating evaluation of robot policies with human input. (3) Collaborative tasks: studying two collaborative tasks, Social Navigation and Social Rearrangement. Social Navigation investigates a robot's ability to locate and follow humanoid avatars in unseen environments, whereas Social Rearrangement addresses collaboration between a humanoid and robot while rearranging a scene. These contributions allow us to study end-to-end learned and heuristic baselines for human-robot collaboration in-depth, as well as evaluate them with humans in the loop. Our experiments demonstrate that learned robot policies lead to efficient task completion when collaborating with unseen humanoid agents and human partners that might exhibit behaviors that the robot has not seen before. Additionally, we observe emergent behaviors during collaborative task execution, such as the robot yielding space when obstructing a humanoid agent, thereby allowing the effective completion of the task by the humanoid agent. Furthermore, our experiments using the human-in-the-loop tool demonstrate that our automated evaluation with humanoids can provide an indication of the relative ordering of different policies when evaluated with real human collaborators. Habitat 3.0 unlocks interesting new features in simulators for Embodied AI, and we hope it paves the way for a new frontier of embodied human-AI interaction capabilities.Comment: Project page: http://aihabitat.org/habitat